- 1914- Babe Ruth signs as a pitcher with the Baltimore Orioles
- 1914- Babe is signed to the Boston Red Sox
- 1914- Babe gets married to Helen Woodford
- 1915- May 6, Babe hits his first major-league run
- 1918- Babe Ruth experiences his first World Series with the Red Sox
- 1919- Babe signs onto the New York Yankees
- 1920- Babe hits a record 54 home runs in one season
- 1921- Yankees play their first World Series, featuring Babe Ruth
- 1923- Babe plays in another World Series with the Yankees
- 1926- Babe hits a record three home runs in one World Series game
- 1927- Babe hits 60 home runs in one season
- 1928- Babe plays in another World Series with the Yankees
- 1929- Babe remarries, after the death of his wife Helen, to Claire Merritt Hodsgon
- 1932- Babe Ruth calls the shot during Game 3 of the World Series against the Cubs
- 1935- Babe signs with the Braves
- 1935- May 30, Babe Ruth plays in his last Major League Baseball game
- 1935- Babe retires from Major League Baseball
- 1936- Babe Ruth is chosen for the National Baseball Hall of Fame
- 1946- Babe is diagnosed with a malignant tumor in his neck
- 1948- August 16, Babe Ruth dies